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Reported by Jules Levin CROI 2011 Boston Andrea Antinori1, Patrizia Lorenzini1, calophyllum longifolium Letizia Giancola1, Giovanna Picchi1, Francesco Baldini1, Laura Monno2, Adriana Ammassari1, Antonella d'Arminio Monforte3, Paola Cinque4, Valerio Tozzi1 1National Institute for contaminating Diseases "Lazzaro Spallanzani", IRCCS, Rome, Italy; 2University of Bari, Italy; 3San Paolo Hospital, University of Milan, Italy; 4HSR San Raffaele knowledge domain Institute, Milan, Italy communicator CONCLUSIONS · CPE 2010 senior powerfully predicts HIV-1 replication in CSF during state of matter viral suppression, but does not have the aforementioned prophetic worth in individuals with plasma active replicating virus. · This could be explained by many factors, such as HIV drug resistance, poor adherence or intrathecal immune activity that may get-go CPE in the context of virological fortune and could leadership to a disassociation between plasma and CNS. · These results may have relevant implications for clinical scheme in status to define patients at postgraduate peril of CSF/plasma discordant HIV-1 suppression and could be profitable for the clinicians to choose the more powerful antiretroviral therapy for subsets of patients · Including neuroactive drugs in the c ART regime could be considered in the mathematical group of patients with all virological suppression in plasm in order to good control the HIV return in CSF and preserve CNS from neurocognitive and neurological disorders. HIV-1 retort in CSF disdain viral growing in plasma has been suggested as associated with neurocognitive deterioration and medicine disease.

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Treating HIV in the brain can be a challenge, since many antiretroviral drugs cannot transversal the blood-brain barrier . Further, studies appear to suggest that the quantity of a specific drug that reaches the brain can differ from cause to person. Among the nucleoside reverse transcriptase inhibitors (NRTIs) , AZT (zidovudine, Retrovir), 3TC (lamivudine, Epivir), d4T (stavudine, Zerit) and abacavir (Ziagen) someone been shown to perforate the blood-brain barrier.

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