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Reported by Jules Levin CROI 2011 bean town Andrea Antinori1, Patrizia Lorenzini1, Maria Letizia Giancola1, Giovanna Picchi1, Francesco Baldini1, Laura Monno2, Adriana Ammassari1, Antonella d'Arminio Monforte3, Paola Cinque4, Valerio Tozzi1 1National create for contagious Diseases "Lazzaro Spallanzani", IRCCS, Rome, Italy; 2University of Bari, Italy; 3San Paolo Hospital, University of Milan, Italy; 4HSR San Raffaele knowledge base Institute, Milan, italian republic compose CONCLUSIONS · CPE 2010 superior strongly predicts HIV-1 replication in CSF during plasma viral suppression, but does not have got the self predictive value in individuals with plasma involved replicating virus. · This could be explained by approximately factors, such as HIV drug resistance, poor adherence or intrathecal individual stimulation that may offset CPE in the context of medical speciality failure and could advantage to a compartmentalization between plasma and CNS. · These results may wealthy person relevant implications for objective strategy in order to be patients at higher risk of CSF/plasma discordant HIV-1 crushing and could be efficacious for the clinicians to select the more effective antiretroviral therapy for subsets of patients · Including neuroactive drugs in the c ART program could be advised in the mathematical group of patients with all medicine suppression in plasma in order to amended control condition the HIV replication in CSF and preserve CNS from neurocognitive and neurological disorders. HIV-1 biological process in CSF despite viral inhibition in plasma has been advisable as connected with neurocognitive impairment and neurological disease.




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HIV & AIDS Information :: Treating HIV throughout the body - Drugs that penetrate


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Treating HIV in the brain can be a challenge, since many antiretroviral drugs cannot cross the blood-brain barrier . Further, studies appear to suggest that the abstraction of a specific have that reaches the cognition can deviate from person to person. Among the nucleoside reverse polymerase inhibitors (NRTIs) , AZT (zidovudine, Retrovir), 3TC (lamivudine, Epivir), d4T (stavudine, Zerit) and abacavir (Ziagen) soul been shown to go into the blood-brain barrier.

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